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Gaitan NC, D’Antoni ML, Acosta RK, Gianella S, Little SJ, Chaillon A. Brief Report: Comparative Analysis of Pre-existing HIV Drug Resistance Mutations in Proviral DNA Using Next-Generation Sequencing and Routine HIV RNA Genotyping. J Acquir Immune Defic Syndr. 2023 Jul 1;93(3):213-218. doi: 10.1097/QAI.0000000000003195. PMID: 36961945; PMCID: PMC10272101.
Ament, S.A., Campbell, R.R., Lobo, M.K. et al. The single-cell opioid responses in the context of HIV (SCORCH) consortium. Mol Psychiatry (2024). https://doi.org/10.1038/s41380-024-02620-7
Ndukwe SO, Patel H, Shelton B, Concha-Garcia S, Dullano C, Solso S, Hendrickx S, Riggs PK, Villa TJ, Kaytes A, Taylor J, Little SJ, Lessard D, Arora AK, Costiniuk CT, Eskaf S, Smith DM, Gianella S, Dubé K. People with HIV at the end-of-life and their next-of-kin/loved ones are willing ...
Rao E, Taylor J, Kaytes A, Concha-Garcia S, Riggs PK, Smith DM, Dubé K, Gianella S. Vulnerability in Biomedical Research: A Historical Reflection and Practical Implications for HIV Cure-Related Research. AIDS Res Hum Retroviruses. 2024 Jan;40(1):22-27. doi: 10.1089/AID.2022.0136. Epub 2023 Jun 21. PMID: 37227023; PMCID: PMC10790546.
Dopkins N, Singh B, Michael S, Zhang P, Marston JL, Fei T, Singh M, Feschotte C, Collins N, Bendall ML, Nixon DF. Ribosomal profiling of human endogenous retroviruses in healthy tissues. BMC Genomics. 2024 Jan 2;25(1):5. doi: 10.1186/s12864-023-09909-x. PMID: 38166631
Helena Reyes-Gopar, Jez L. Marston, Bhavya Singh, Matthew Greenig, Jonah Lin, Mario A. Ostrowski, Kipchoge N. Randall Jr., Santiago Sandoval-Motta, Nicholas Dopkins, Elsa Lawrence, Morgan M. O’Mara, Tongyi Fei, Rodrigo R. R. Duarte, Timothy R. Powell, Enrique Hernández-Lemus, Luis P. Iñiguez, Douglas F. Nixon, Matthew L. Bendall doi: https://doi.org/10.1101/2023.12.28.573568
Tuma, Jan; Chen, Yu-Ju; Collins, Michael G; Paul, Abhik; Li, Jie; Han, Hesong; Sharma, Rohit; Murthy, Niren; Lee, Hye Young Lipid Nanoparticles Deliver mRNA to the Brain after an Intracerebral Injection. Biochemistry2023 Dec 19; 62 (24) 3533-3547
Boehm D, Kaehlcke K, Schnoelzer M, Ott M. Protocol for an in vitro assay to study HIV-1 Tat methylation. STAR Protoc. 2023 Nov 17;4(4):102687. doi: 10.1016/j.xpro.2023.102687. Epub ahead of print. PMID: 37979180; PMCID: PMC10694577.
Singh M, Leddy SM, Iñiguez LP, Bendall ML, Nixon DF, Feschotte C. Transposable elements may enhance antiviral resistance in HIV-1 elite controllers. bioRxiv. 2023 Dec 12:2023.12.11.571123. doi: 10.1101/2023.12.11.571123. Preprint. PMID: 38168352
3D Human Tissue Models for HIV Working Group. Electronic address: dwight.yin@nih.gov. 3D human tissue models and microphysiological systems for HIV and related comorbidities. Trends Biotechnol. 2023 Dec 8:S0167-7799(23)00299-8. doi: 10.1016/j.tibtech.2023.10.008. Epub ahead of print. PMID: 38071144.
Ndhlovu LC, Bendall ML, Dwaraka V, Pang AP, Dopkins N, Carreras N, Smith R, Nixon DF, Corley MJ. Retroelement-Age Clocks: Epigenetic Age Captured by Human Endogenous Retrovirus and LINE-1 DNA methylation states. bioRxiv [Preprint]. 2023 Dec 7:2023.12.06.570422. doi: 10.1101/2023.12.06.570422. PMID: 38106164; PMCID: PMC10723416
6. Boehm D, Ott M. A flow cytometry-based assay to investigate HIV-1 expression in SMYD5 shRNA containing primary CD4+ T cells. STAR Protoc. 2023 Nov 4;4(4):102694. doi: 10.1016/j.xpro.2023.102694. Epub ahead of print. PMID: 37925635; PMCID: PMC10751565.
Srinivasachar Badarinarayan, Smitha; Sauter, Daniel Not all viruses cause disease: HERV-K(HML-2) in healthy human tissues. PLoS biology2022 Oct; 20 (10) e3001884
Lyons, D.E.; Kumar, P.; Roan, N.R.; Defechereux, P.A.; Feschotte, C.; Lange, U.C.; Murthy, N.; Sameshima, P.; Verdin, E.; Ake, J.A.; Furler O’Brien, R.; et al. HIV-1 Remission: Accelerating the Path to Permanent HIV-1 Silencing. Viruses 2023, 15, 2171. https://doi.org/10.3390/v15112171
Preeti Moar, Thomas A. Premeaux, Andrew Atkins, Lishomwa C. Ndhlovu and Vinayaka R. Prasad
Li Z, Deeks SG, Ott M, Greene WC. Comprehensive synergy mapping links a BAF- and NSL-containing “supercomplex” to the transcriptional silencing of HIV-1. Cell Rep. 2023 Sep 26;42(9):113055. doi: 10.1016/j.celrep.2023.113055. Epub 2023 Sep 7. PMID: 37682714; PMCID: PMC10591912.
Goyal R, De Gruttola V, Gianella S, Caballero G, Porrachia M, Ignacio C, Woodworth B, Smith DM, Chaillon A. Identification of system-level features in HIV migration within a host. PLoS One. 2023 Sep 26;18(9):e0291367. doi: 10.1371/journal.pone.0291367. PMID: 37751407; PMCID: PMC10521982.
Exploiting a rodent cell block for intrinsic resistance to HIV-1 gene expression in human T cells Ryan T. Behrens rtbehrens@wisc.edu , Jyothi Krishnaswamy Rajashekar , James W. Bruce , Edward L. Evans, III , Amelia M. Hansen , Natalia Salazar-Quiroz , Lacy M. Simons , Paul Ahlquist , Judd F. Hultquist , Priti Kumar , Nathan M. Sherer nsherer@wisc.edu
Corley MJ, Pang APS, Shikuma CM, Ndhlovu LC. Cell-type specific impact of metformin on monocyte epigenetic age reversal in virally suppressed older people living with HIV. Aging Cell. 2023 Sep 7:e13926. doi: 10.1111/acel.13926. Epub ahead of print. PMID: 37675817.
Gibaut QMR, Mori LP, Valente ST. HIV-1 transcriptional modulation: novel host factors and prospective therapeutic strategies. Curr Opin HIV AIDS. 2023 Sep 1;18(5):264-272. doi: 10.1097/COH.0000000000000808. Epub 2023 Jul 17. PMID: 37535041; PMCID: PMC10403276.
Trunfio M, Chaillon A, Beliakova-Bethell N, Deiss R, Letendre SL, Riggs PK, Higgins N, Gianella S. Beyond the Syndemic of Opioid Use Disorders and HIV: The Impact of Opioids on Viral Reservoirs. Viruses. 2023 Aug 9;15(8):1712. doi: 10.3390/v15081712. PMID: 37632053; PMCID: PMC10458944.
Bianchi L, Fiorentini S, Gianella S, Gianotti S, Iadanza C, Asadi S, Saccomandi P. Measurement of Thermal Conductivity and Thermal Diffusivity of Porcine and Bovine Kidney Tissues at Supraphysiological Temperatures up to 93 °C. Sensors (Basel). 2023 Aug 2;23(15):6865. doi: 10.3390/s23156865. PMID: 37571648; PMCID: PMC10422510
Popovitz, Juliana; Sharma, Rohit; Hoshyar, Reyhane; Soo Kim, Beob; Murthy, Niren; Lee, Kunwoo Gene editing therapeutics based on mRNA delivery. Advanced drug delivery reviews2023 Sep; 200 115026
Chen, X., Wang, Y., Cappuccio, A. et al. Mapping disease regulatory circuits at cell-type resolution from single-cell multiomics data. Nat Comput Sci 3, 644–657 (2023). https://doi.org/10.1038/s43588-023-00476-5
Hastie E, Moser C, Sun X, Lennox J, Hsue PY, Bosch RJ, Deeks S, Meneses MV, Lederman MM, Hunt P, Henrich TJ, Marconi VC, Gianella S. Effect of Immune-Modulatory Interventions on Asymptomatic Cytomegalovirus Shedding During Suppressive Antiretroviral Therapy. J Infect Dis. 2023 Jun 28;228(1):64-69. doi: 10.1093/infdis/jiad060. PMID: 36881933; PMCID: PMC10490531
Manca A, De Nicolò A, De Vivo ED, Ferrara M, Oh S, Khalili S, Higgins N, Deiss RG, Bonora S, Cusato J, Palermiti A, Mula J, Gianella S, D’Avolio A. A Novel UHPLC-MS/MS Method for the Quantification of Seven Opioids in Different Human Tissues. Pharmaceuticals (Basel). 2023 Jun 19;16(6):903. doi: ...
Tang Y, Chaillon A, Gianella S, Wong LM, Li D, Simermeyer TL, Porrachia M, Ignacio C, Woodworth B, Zhong D, Du J, de la Parra Polina E, Kirchherr J, Allard B, Clohosey ML, Moeser M, Sondgeroth AL, Whitehill GD, Singh V, Dashti A, Smith DM, Eron JJ, Bar KJ, Chahroudi ...
Ahuja SK, Manoharan MS, Lee GC, McKinnon LR, Meunier JA, Steri M, Harper N, Fiorillo E, Smith AM, Restrepo MI, Branum AP, Bottomley MJ, Orrù V, Jimenez F, Carrillo A, Pandranki L, Winter CA, Winter LA, Gaitan AA, Moreira AG, Walter EA, Silvestri G, King CL, Zheng YT, Zheng HY, ...
Bajaj T, Wehri E, Suryawanshi RK, King E, Pardeshi KS, Behrouzi K, Khodabakhshi Z, Schulze-Gahmen U, Kumar GR, Mofrad MRK, Nomura DK, Ott M, Schaletzky J, Murthy N. Mercapto-pyrimidines are reversible covalent inhibitors of the papain-like protease (PLpro) and inhibit SARS-CoV-2 (SCoV-2) replication. RSC Adv. 2023 Jun 12;13(26):17667-17677. doi: 10.1039/d3ra01915b. ...
Karine Dubé DrPH, Tia Morton RN, Lawrence Fox MD, Lynda Dee JD, David Palm MS, Thomas J Villa, William Freshwater, Jeff Taylor, Gail Graham, William B Carter, John A Sauceda PhD, Michael J Peluso MD, Annette Rid MD
Dubé K, Shelton B, Patel H, Ndukwe SO, Concha-Garcia S, Dullano C, Solso S, Hendrickx S, Kaytes A, Taylor J, Villa TJ, Little SJ, Riggs PK, Lessard D, Arora AK, Costiniuk CT, Eskaf S, Smith DM, Gianella S. Perceived risks and benefits of enrolling people with HIV at the end ...
Dubé K, Villa TJ, Taylor J, Kaytes A, Moore DJ, Little SJ, Chaillon A, Smith DM, Gianella S. A Community-Driven Framework to Prioritize the Use of Donated Human Biological Materials in the Context of HIV Cure-Related Research at the End of Life. Pathog Immun. 2023 May 24;8(1):1-16. doi: 10.20411/pai.v8i1.583. PMID: ...
Ken, M.L., Roy, R., Geng, A. et al. RNA conformational propensities determine cellular activity. Nature 617, 835–841 (2023). https://doi.org/10.1038/s41586-023-06080-x
Oliveira MF, Pankow A, Vollbrecht T, Kumar NM, Cabalero G, Ignacio C, Zhao M, Vitomirov A, Gouaux B, Nakawawa M, Murrell B, Ellis RJ, Gianella S. Evaluation of Archival HIV DNA in Brain and Lymphoid Tissues. J Virol. 2023 Jun 29;97(6):e0054323. doi: 10.1128/jvi.00543-23. Epub 2023 May 15. PMID: 37184401; PMCID: ...
Kanazawa J, Rawlings SA, Hendrickx S, Gianella S, Concha-Garcia S, Taylor J, Kaytes A, Patel H, Ndukwe S, Little SJ, Smith D, Dubé K. Lessons learned from the Last Gift study: ethical and practical challenges faced while conducting HIV cure-related research at the end of life. J Med Ethics. 2023 ...
Wanjalla CN, Simmons J, Oakes J, Zhang X, Nochowicz C, Priest S, Bailin SS, Warren CM, Mashayekhi M, Beasley HK, Wang J, Meenderink L, Sheng Q, Stolze J, Gangula R, Chopra A, Gabriel CL, Temu T, Pakala S, Wilfong EM, Gianella S, Phillips EJ, Harrison DG, Hinton A, Kalams SA, ...
19. George AF, Roan NR. Advances in HIV Research Using Mass Cytometry. Current HIV/AIDS Reports. 2023. 20(2):76-85. PubMed PMID: 3668119; PubMed Central PMCID: PMC9869313.
Ling, Lijun; Leda, Ana R; Begum, Nurjahan; Spagnuolo, Rae Ann; Wahl, Angela; Garcia, J Victor; Valente, Susana T. Loss of In Vivo Replication Fitness of HIV-1 Variants Resistant to the Tat Inhibitor, dCA. Viruses2023 Apr 12; 15 (4)
Taylor BC, Sheikh Andalibi M, Wandro S, Weldon KC, Sepich-Poore GD, Carpenter CS, Fraraccio S, Franklin D, Iudicello JE, Letendre S, Gianella S, Grant I, Ellis RJ, Heaton RK, Knight R, Swafford AD. Signatures of HIV and Major Depressive Disorder in the Plasma Microbiome. Microorganisms. 2023 Apr 14;11(4):1022. doi: 10.3390/microorganisms11041022. ...
Dubé K, Barr E, Philbin M, Perez-Brumer A, Minalga B, Peterson B, Averitt D, Picou B, Martel K, Chung C, Mejía M, Cameron M, Graham G, Dee L, Dixon Diallo D, Gordon E, Korolkova A, Dyer T, Auerbach JD, Scully E, Dong KL, Gianella S. Increasing the meaningful involvement of ...
Hamann, M.V., Adiba, M. & Lange, U.C. Confounding factors in profiling of locus-specific human endogenous retrovirus (HERV) transcript signatures in primary T cells using multi-study-derived datasets. BMC Med Genomics 16, 68 (2023). https://doi.org/10.1186/s12920-023-01486-y
Joseph SB, Gianella S, Burdo TH, Cinque P, Gisslen M, Letendre S, Nath A, Morgello S, Ndhlovu LC, Spudich S. Biotypes of Central Nervous System Complications in People With Human Immunodeficiency Virus: Virology, Immunology, and Neuropathology. J Infect Dis. 2023 Mar 17;227(Suppl 1):S3-S15. doi: 10.1093/infdis/jiac370. PMID: 36930640; PMCID: PMC10022721.
Boehm D, Lam V, Schnolzer M, Ott M. The lysine methyltransferase SMYD5 amplifies HIV-1 transcription and is post-transcriptionally upregulated by Tat and USP11. Cell Rep. 2023 Mar 9;42(3):112234. doi: 10.1016/j.celrep.2023.112234. Epub ahead of print. PMID: 36897778.
Mukim, Amey; Smith, Davey M; Deshmukh, Savitha; Qazi, Andrew A; Beliakova-Bethell, Nadejda A Camptothetin Analog, Topotecan, Promotes HIV Latency via Interference with HIV Transcription and RNA Splicing. Journal of virology2023 Feb 28; 97 (2) e0163022
Wanjalla CN, Gabriel CL, Fuseini H, Bailin SS, Mashayekhi M, Simmons J, Warren CM, Glass DR, Oakes J, Gangula R, Wilfong E, Priest S, Temu T, Newell EW, Pakala S, Kalams SA, Gianella S, Smith D, Harrison DG, Mallal SA, Koethe JR. CD4+ T cells expressing CX3CR1, GPR56, with variable ...
Chuan Li, Luisa P. Mori, Shuang Lyu, Ronald Bronson, Adam J. Getzler, Matthew E. Pipkin, and Susana T. Valente
Yuan Z, Giron LB, Hart C, Gyampoh A, Koshy J, Hong KY, Niki T, Premeaux TA, Ndhlovu LC, Deleage C, Montaner LJ, Abdel-Mohsen M.
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Packard, Thomas A; Schwarzer, Roland; Herzig, Eytan; Rao, Deepashri; Luo, Xiaoyu; Egedal, Johanne H; Hsiao, Feng; Widera, Marek; Hultquist, Judd F; Grimmett, Zachary W; Messer, Ronald J; Krogan, Nevan J; Deeks, Steven G; Roan, Nadia R; Dittmer, Ulf; Hasenkrug, Kim J; Greene, Warner C. CCL2: a Chemokine Potentially Promoting Early ...
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Curty G, Iniguez LP, Soares MA, Nixon DF, de Mulder Rougvie M.
Shelli F. Farhadian,1,2 Ofir Lindenbaum,3,4 Jun Zhao,4,5 Michael J. Corley,6,7 Yunju Im,8 Hannah Walsh,1 Alyssa Vecchio,9 Rolando Garcia-Milian,10 Jennifer Chiarella,2 Michelle Chintanaphol,2 Rachela Calvi,2 Guilin Wang,11 Lishomwa C. Ndhlovu,6,7 Jennifer Yoon,1 Diane Trotta,5 Shuangge Ma,8 Yuval Kluger,3,4,12 and Serena Spudich2
Ma T, McGregor M, Giron L, Xie G, George AF, Abdel-Mohsen M, Roan NR.
Luo X, Frouard J, Zhang G, Neidleman J, Xie G, Sheedy E, Roan NR, Greene WC.
Li, Jie; Tuma, Jan; Han, Hesong; Kim, Hansol; Wilson, Ross C; Lee, Hye Young; Murthy, Niren The Coiled-Coil Forming Peptide (KVSALKE)5 Is a Cell Penetrating Peptide that Enhances the Intracellular Delivery of Proteins. Advanced healthcare materials2022 May; 11 (9) e2102118
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25. Hardwick, Simon A; Hu, Wen; Joglekar, Anoushka; Fan, Li; Collier, Paul G; Foord, Careen; Balacco, Jennifer; Lanjewar, Samantha; Sampson, Maureen McGuirk; Koopmans, Frank; Prjibelski, Andrey D; Mikheenko, Alla; Belchikov, Natan; Jarroux, Julien; Lucas, Anne Bergstrom; Palkovits, Miklós; Luo, Wenjie; Milner, Teresa A; Ndhlovu, Lishomwa C; Smit, August B; Trojanowski, ...
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Gislaine Curty, Luis P. Iñiguez, Douglas F. Nixon, Marcelo A. Soares and Miguel de Mulder Rougvie.